Early Mechanisms of Renal Injury in Hypercholesterolemic or Hypertriglyceridemic Rats
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چکیده
منابع مشابه
Early mechanisms of renal injury in hypercholesterolemic or hypertriglyceridemic rats.
Hyperlipidemia in conjunction with uninephrectomy leads to renal injury in rats. It is unknown whether this is due to mesangial cell or podocyte injury and whether the injuries induced by hypercholesterolemia and hypertriglyceridemia share a similar pathogenesis. Therefore, renal effects of hypercholesterolemia were studied in male rats with dietary hypercholesterolemia compared with rats on a ...
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Diabetes mellitus is a progressive disease. Most investigators have focused on glomerular changes in diabetic kidney and non-glomerular alterations have been less attended. The present study has been conducted to find early non-glomerular histological changes in diabetic renal tissue. Twenty male Wistar rats weighting 200-250 g were used for the diabetic group. Diabetes mellitus was induced by ...
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The microcirculatory changes caused by hypercholesterolemia were studied in the rat cremaster muscle model by intravital microscopy and were compared with aortic ring segments from the same animals. Male Sprague-Dawley rats were fed either a normal chow diet or a chow diet supplemented with 1% cholesterol and 0.5% cholic acid for 3 or 5 weeks before experimentation. Three weeks of hypercholeste...
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Nonenzymatic collagen glycation and modification with lipid derived metabolites was studied in rat skin and tail tendon collagen of control and hypertriglyceridemic (HTG) rats. Age-dependent changes typical for lipid and sugar derived adducts were evaluated by measuring fluorescence of these collagens at wavelengths typical for sugar (335/385 and 370/440 nm) and lipid derived adducts (356/460 a...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2000
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v114669